|Full Name||cytokine inducible SH2-containing protein|
|Product Description||Rabbit Polyclonal antibody to CIS (cytokine inducible SH2-containing protein)|
|Background||The protein encoded by this gene contains a SH2 domain and a SOCS box domain. The protein thus belongs to the cytokine-induced STAT inhibitor (CIS), also known as suppressor of cytokine signaling (SOCS) or STAT-induced STAT inhibitor (SSI), protein family. CIS family members are known to be cytokine-inducible negative regulators of cytokine signaling. The expression of this gene can be induced by IL2, IL3, GM-CSF and EPO in hematopoietic cells. Proteasome-mediated degradation of this protein has been shown to be involved in the inactivation of the erythropoietin receptor. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq]|
|Synonyms||CIS antibody, CIS-1 antibody, G18 antibody, SOCS antibody, CISH antibody, suppressor of cytokine signaling antibody, cytokine-inducible inhibitor of signaling type 1B antibody, cytokine-inducible SH2-containing protein antibody, cytokine inducible SH2-containing protein antibody|
|Immunogen||Carrier-protein conjugated synthetic peptide encompassing a sequence within the C-terminus region of human CIS. The exact sequence is proprietary.|
|Species Reactivity||Human, Rat|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Mouse, Pig, Rhesus Monkey, Bovine|
|Predict Reactivity Note||Mouse (100%), Pig (100%), Rhesus Monkey (100%), Bovine (100%)|