|Full Name||chloride intracellular channel 4|
|Product Description||Goat polyclonal antibody to CLIC4|
|Background||Can insert into membranes and form poorly selective ion channels that may also transport chloride ions. Channel activity depends on the pH. Membrane insertion seems to be redox-regulated and may occur only under oxydizing conditions. Promotes cell-surface expression of HRH3. Has alternate cellular functions like a potential role in angiogenesis or in maintaining apical-basolateral membrane polarity during mitosis and cytokinesis. Could also promote endothelial cell proliferation and regulate endothelial morphogenesis (tubulogenesis). |
|Synonyms||p64H1, chloride intracellular channel 4 like, CLIC4L, H1, chloride intracellular channel4, DKFZP566G223, chloride intracellular channel 4, CLIC4, chloride intracellular channel4 like, huH1, FLJ38640, MTCLIC|
|Cellular Localization||Colocalized with AKAP9 at the centrosome and midbody. Exists both as soluble cytoplasmic protein and as membrane protein with probably a single transmembrane domain. Present in an intracellular vesicular compartment that likely represent trans-Golgi netwo|
|Specificity||This antibody is specific for CLIC4.|
|Species Reactivity||Human, Mouse|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.