|Full Name||CLP1, cleavage and polyadenylation factor I subunit, homolog (S. cerevisiae)|
|Product Description||Rabbit Polyclonal antibody to CLP1 (CLP1, cleavage and polyadenylation factor I subunit, homolog (S. cerevisiae))|
|Background||Polynucleotide kinase that can phosphorylate the 5'-hydroxyl groups of double-stranded RNA (dsRNA), single-stranded RNA (ssRNA), double stranded DNA (dsDNA) and double-stranded DNA:RNA hybrids. dsRNA is phosphorylated more efficiently than dsDNA, and the RNA component of a DNA:RNA hybrid is phosphorylated more efficiently than the DNA component. Appears to have roles in both tRNA splicing and mRNA 3'-end formation. Component of the tRNA splicing endonuclease complex. Phosphorylates the 5'-terminus of the tRNA 3'-exon during tRNA splicing; this phosphorylation event is a prerequisite for the subsequent ligation of the two exon halves and the production of a mature tRNA. Component of the pre-mRNA cleavage complex II (CF-II), which seems to be required for mRNA 3'-end formation. Also phosphorylates the 5'-terminus of exogenously introduced short interfering RNAs (siRNAs), which is a necessary prerequisite for their incorporation into the RNA-induced silencing complex (RISC). However endogenous siRNAs and microRNAs (miRNAs) that are produced by the cleavage of dsRNA precursors by DICER1 already contain a 5'-phosphate group, so this protein may be dispensible for normal RNA-mediated gene silencing.|
|Synonyms||HEAB antibody, hClp1 antibody, CLP1 antibody, pre-mRNA cleavage complex II protein Clp1 antibody, homolog of yeast CFIA subunit Clp1p antibody, polynucleotide kinase Clp1 antibody, polyribonucleotide 5'-hydroxyl-kinase Clp1 antibody, ATP/GTP-binding protein antibody, "CLP1, cleavage and polyadenylation factor I subunit, homolog (S. cerevisiae) antibody"|
|Immunogen||Recombinant protein encompassing a sequence within the center region of human CLP1. The exact sequence is proprietary.|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Mouse, Rat, Xenopus laevis, Chicken, Rhesus Monkey, Chimpanzee, Bovine|
|Predict Reactivity Note||Mouse (99%), Rat (99%), Xenopus laevis (82%), Chicken (98%), Rhesus Monkey (92%), Chimpanzee (100%), Bovine (100%)|