|Full Name||cofactor of BRCA1|
|Product Description||Rabbit Polyclonal antibody to COBRA1 (cofactor of BRCA1)|
|Background||NELFB is a subunit of negative elongation factor (NELF), which also includes NELFA (WHSC2; MIM 606026), either NELFC or NELFD (TH1L; MIM 605297), and NELFE (RDBP; MIM 154040). NELF acts with DRB sensitivity-inducing factor (DSIF), a heterodimer of SPT4 (SUPT4H1; MIM 603555) and SPT5 (SUPT5H; MIM 602102), to cause transcriptional pausing of RNA polymerase II (see MIM 180660) (Narita et al., 2003 [PubMed 12612062]).[supplied by OMIM]|
|Synonyms||DKFZp586B0519 antibody, KIAA1182 antibody, NELF-B antibody, NELFB antibody, COBRA1 antibody, negative elongation factor protein B antibody, negative elongation factor B antibody, cofactor of BRCA1 antibody|
|Cellular Localization||Nucleus |
|Immunogen||Recombinant protein encompassing a sequence within the center region of human COBRA1. The exact sequence is proprietary.|
|Species Reactivity||Human, Mouse|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Rat, Zebrafish, Xenopus laevis, Pig, Chicken|
|Predict Reactivity Note||Rat (99%), Zebrafish (86%), Xenopus laevis (85%), Pig (97%), Chicken (92%)|