|Full Name||collagen, type I, alpha 1|
|Product Description||Rabbit Polyclonal antibody to COL1A1 (collagen, type I, alpha 1)|
|Background||This gene encodes the pro-alpha1 chains of type I collagen whose triple helix comprises two alpha1 chains and one alpha2 chain. Type I is a fibril-forming collagen found in most connective tissues and is abundant in bone, cornea, dermis and tendon. Mutations in this gene are associated with osteogenesis imperfecta types I-IV, Ehlers-Danlos syndrome type VIIA, Ehlers-Danlos syndrome Classical type, Caffey Disease and idiopathic osteoporosis. Reciprocal translocations between chromosomes 17 and 22, where this gene and the gene for platelet-derived growth factor beta are located, are associated with a particular type of skin tumor called dermatofibrosarcoma protuberans, resulting from unregulated expression of the growth factor. Two transcripts, resulting from the use of alternate polyadenylation signals, have been identified for this gene. [provided by R. Dalgleish]|
|Synonyms||OI4 antibody, COL1A1 antibody, collagen alpha-1(I) chain antibody, pro-alpha-1 collagen type 1 antibody, alpha-1 type I collagen antibody, "collagen of skin, tendon and bone, alpha-1 chain antibody", collagen alpha 1 chain type I antibody, "collagen, type I, alpha 1 antibody"|
|Cellular Localization||Secreted , extracellular space , extracellular matrix |
|Immunogen||Recombinant protein encompassing a sequence within the N-terminus region of human COL1A1. The exact sequence is proprietary.|
|Species Reactivity||Human, Mouse|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Rat, Dog, Bovine|
|Predict Reactivity Note||Rat (94%), Dog (98%), Bovine (98%)|