|Full Name||collagen, type I, alpha 2|
|Product Description||Rabbit Polyclonal antibody to COL1A2 (collagen, type I, alpha 2)|
|Background||This gene encodes the pro-alpha2 chain of type I collagen whose triple helix comprises two alpha1 chains and one alpha2 chain. Type I is a fibril-forming collagen found in most connective tissues and is abundant in bone, cornea, dermis and tendon. Mutations in this gene are associated with osteogenesis imperfecta types I-IV, Ehlers-Danlos syndrome type VIIB, recessive Ehlers-Danlos syndrome Classical type, idiopathic osteoporosis, and atypical Marfan syndrome. Symptoms associated with mutations in this gene, however, tend to be less severe than mutations in the gene for the alpha1 chain of type I collagen (COL1A1) reflecting the different role of alpha2 chains in matrix integrity. Three transcripts, resulting from the use of alternate polyadenylation signals, have been identified for this gene. [provided by R. Dalgleish]|
|Synonyms||OI4 antibody, COL1A2 antibody, collagen I, alpha-2 polypeptide antibody, collagen of skin, tendon and bone, alpha-2 chain antibody, type I procollagen antibody, collagen alpha-2(I) chain antibody, alpha 2(I)-collagen antibody, alpha-2 type I collagen antibody, collagen, type I, alpha 2 antibody|
|Cellular Localization||Secreted , extracellular space , extracellular matrix |
|Immunogen||Recombinant protein encompassing a sequence within the C-terminus region of human COL1A2. The exact sequence is proprietary.|
|Species Reactivity||Human, Mouse|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Rat, Dog, Pig, Rabbit, Chicken, Rhesus Monkey, Bovine|
|Predict Reactivity Note||Rat (88%), Dog (95%), Pig (95%), Rabbit (90%), Chicken (82%), Rhesus Monkey (100%), Bovine (93%)|