|Product Description||Rabbit Polyclonal antibody to COMT (catechol-O-methyltransferase)|
|Background||Catechol-O-methyltransferase catalyzes the transfer of a methyl group from S-adenosylmethionine to catecholamines, including the neurotransmitters dopamine, epinephrine, and norepinephrine. This O-methylation results in one of the major degradative pathways of the catecholamine transmitters. In addition to its role in the metabolism of endogenous substances, COMT is important in the metabolism of catechol drugs used in the treatment of hypertension, asthma, and Parkinson disease. COMT is found in two forms in tissues, a soluble form (S-COMT) and a membrane-bound form (MB-COMT). The differences between S-COMT and MB-COMT reside within the N-termini. Several transcript variants are formed through the use of alternative translation initiation sites and promoters. [provided by RefSeq]|
|Synonyms||COMT antibody, catechol O-methyltransferase antibody, catechol-O-methyltransferase antibody|
|Cellular Localization||Isoform Soluble: Cytoplasm , Isoform Membrane-bound: Cell membrane |
|Immunogen||Recombinant protein encompassing a sequence within the center region of human COMT. The exact sequence is proprietary.|
|Species Reactivity||Human, Mouse|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Rat, Dog, Pig, Rhesus Monkey, Bovine|
|Predict Reactivity Note||Rat (82%), Dog (81%), Pig (82%), Rhesus Monkey (93%), Bovine (81%)|