COX1 antibody [C3], C-term
Not tested in other applications.
|IHC (Formalin-fixed paraffin-embedded sections)||1:100-1:1000*
*Optimal dilutions/concentrations should be determined by the researcher.
|Predicted Target Size||69 kDa (note)
|Positive Controls||293T , A431 , HepG2 , Molt-4 , Raji |
(Please refer to the vial label for the specific concentration)|
|Purification||Purified by antigen-affinity chromatography.|
|Full Name||prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)|
|Product Description||Rabbit polyclonal antibody to COX1 (prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase))|
|Background||Prostaglandin-endoperoxide synthase (PTGS), also known as cyclooxygenase, is the key enzyme in prostaglandin biosynthesis, and acts both as a dioxygenase and as a peroxidase. There are two isozymes of PTGS: a constitutive PTGS1 and an inducible PTGS2, which differ in their regulation of expression and tissue distribution. This gene encodes PTGS1, which regulates angiogenesis in endothelial cells, and is inhibited by nonsteroidal anti-inflammatory drugs such as aspirin. PTGS1 is thought to be involved in cell-cell signaling and maintaining tissue homeostasis. Alternative splicing of this gene generates two transcript variants. The expression of these two transcripts is differentially regulated by relevant cytokines and growth factors. [provided by RefSeq]|
|Synonyms||COX1 antibody, COX3 antibody, PCOX1 antibody, PGG/HS antibody, PGHS-1 antibody, PGHS1 antibody, PHS1 antibody, PTGHS antibody, PTGS1 antibody, prostaglandin G/H synthase 1 antibody, cyclooxygenase-1 antibody, PGH synthase 1 antibody, COX-1 antibody, prostaglandin H2 synthase 1 antibody, PHS 1 antibody, prostaglandin G/H synthase and cyclooxygenase antibody, prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase) antibody|
|Cellular Localization||Microsome membrane; Peripheral membrane protein , Endoplasmic reticulum membrane; Peripheral membrane protein |
|Immunogen||Carrier-protein conjugated synthetic peptide encompassing a sequence within the C-terminus region of human COX1. The exact sequence is proprietary.|