| Full Name | cytoplasmic polyadenylation element binding protein 1 |
| Background | The regulated translation of messenger RNA is essential for cell-cycle progression, establishment of the body plan during early development, and modulation of key activities in the central nervous system. Cytoplasmic polyadenylation, which is one mechanism of controlling translation, is driven by CPEB (Cytoplasmic Polyadenylation Element Binding protein), a highly conserved, sequence specific RNA binding protein that binds to the cytoplasmic polyadenylation element, and modulates translational repression and mRNA localization. In both vertebrates and invertebrates, the expression of several maternal mRNAs is regulated by cytoplasmic polyadenylation. In Xenopus oocytes, where most of the biochemical details of this process have been examined, polyadenylation is controlled by CPEB. Early metazoan development is programmed by maternal mRNAs inherited by the egg at the time of fertilization. These mRNAs are not translated en masse at any one time or at any one place, but instead their expression is regulated both temporally and spatially. Mammalian neurons, particularly in the synapto dendritic compartment, also contain localized mRNAs such as that encoding alpha CaMKII. Here, synaptic activation drives local translation, an event that is involved in synaptic plasticity and possibly long term memory storage. Synaptic translation of alpha CaMKII mRNA also appears to be controlled by CPEB, which is enriched in the postsynaptic density. Therefore, CPEB controlled local translation may influence such seemingly disparate processes as the cell cycle and synaptic plasticity. |
| Synonyms | CEBP, CPEbinding protein1, CPE-BP1, CPEbinding protein 1, MGC60106, cytoplasmic polyadenylation element binding protein1, cytoplasmic polyadenylation element binding protein 1, CPEB, FLJ13203, MGC34136, CPE-binding protein 1, CPEB1, CPEBP1, CPE BP1, CPE binding protein 1 |
| Cellular Localization | Cytoplasmic |
| Specificity | This antibody is specific for CPEB1. |
| Host | Goat |
| Clonality | Polyclonal |
| Isotype | IgG |
| Immunogen | C-PLMRNQKNRDSS |
| Antigen Species | Human |
| Species Reactivity | Human |
Predicted Cross Reactivity species  Predicted cross-reactivity:
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
| Bovine |
| Conjugation | Unconjugated |