|Full Name||cleavage and polyadenylation specific factor 4, 30kDa|
|Product Description||Rabbit Polyclonal antibody to CPSF4 (cleavage and polyadenylation specific factor 4, 30kDa)|
|Background||Inhibition of the nuclear export of poly(A)-containing mRNAs caused by the influenza A virus NS1 protein requires its effector domain. The NS1 effector domain functionally interacts with the cellular 30 kDa subunit of cleavage and polyadenylation specific factor 4, an essential component of the 3' end processing machinery of cellular pre-mRNAs. In influenza virus-infected cells, the NS1 protein is physically associated with cleavage and polyadenylation specific factor 4, 30kD subunit. Binding of the NS1 protein to the 30 kDa protein in vitro prevents CPSF binding to the RNA substrate and inhibits 3' end cleavage and polyadenylation of host pre-mRNAs. Thus the NS1 protein selectively inhibits the nuclear export of cellular, and not viral, mRNAs. Multiple alternatively spliced transcript variants that encode different isoforms have been described for this gene. [provided by RefSeq]|
|Synonyms||CPSF30 antibody, NAR antibody, NEB1 antibody, CPSF4 antibody, cleavage and polyadenylation specificity factor 30 kDa subunit antibody, neb-1 antibody, cleavage and polyadenylation specificity factor subunit 4 antibody, no arches-like zinc finger protein antibody, "cleavage-polyadenylation specificity factor, 30kD antibody", CPSF 30 kDa subunit antibody, NS1 effector domain-binding protein 1 antibody, no arches homolog antibody, "cleavage and polyadenylation specific factor 4, 30kDa antibody"|
|Immunogen||Recombinant protein encompassing a sequence within the center region of human CPSF4. The exact sequence is proprietary.|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Mouse, Rat, Zebrafish, Xenopus laevis, Chicken, Rhesus Monkey, Bovine|
|Predict Reactivity Note||Mouse (98%), Rat (97%), Zebrafish (84%), Xenopus laevis (88%), Chicken (93%), Rhesus Monkey (100%), Bovine (97%)|