|Full Name||v-crk sarcoma virus CT10 oncogene homolog (avian)|
|Product Description||Rabbit Polyclonal antibody to CRK (v-crk sarcoma virus CT10 oncogene homolog (avian))|
|Background||This gene encodes a member of an adapter protein family that binds to several tyrosine-phosphorylated proteins. The product of this gene has several SH2 and SH3 domains (src-homology domains) and is involved in several signaling pathways, recruiting cytoplasmic proteins in the vicinity of tyrosine kinase through SH2-phosphotyrosine interaction. The N-terminal SH2 domain of this protein functions as a positive regulator of transformation whereas the C-terminal SH3 domain functions as a negative regulator of transformation. Two alternative transcripts encoding different isoforms with distinct biological activity have been described. [provided by RefSeq]|
|Synonyms||CRKII antibody, CRK antibody, adapter molecule crk antibody, proto-oncogene c-Crk antibody, v-crk sarcoma virus CT10 oncogene homolog (avian) antibody|
|Cellular Localization||Cytoplasm , Cell membrane |
|Immunogen||Recombinant protein encompassing a sequence within the center region of human CRK. The exact sequence is proprietary.|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Mouse, Rat, Pig, Bovine|
|Predict Reactivity Note||Mouse (99%), Rat (100%), Pig (100%), Bovine (100%)|