| Full Name | v-crk sarcoma virus CT10 oncogene homolog (avian) |
| Background | This gene encodes a member of an adapter protein family that binds to several tyrosine-phosphorylated proteins. The product of this gene has several SH2 and SH3 domains (src-homology domains) and is involved in several signaling pathways, recruiting cytoplasmic proteins in the vicinity of tyrosine kinase through SH2-phosphotyrosine interaction. The N-terminal SH2 domain of this protein functions as a positive regulator of transformation whereas the C-terminal SH3 domain functions as a negative regulator of transformation. Two alternative transcripts encoding different isoforms with distinct biological activity have been described. [provided by RefSeq] |
| Synonyms | CRKII antibody, CRK antibody, adapter molecule crk antibody, proto-oncogene c-Crk antibody, v-crk sarcoma virus CT10 oncogene homolog (avian) antibody |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Immunogen | Recombinant protein encompassing a sequence within the center region of human CRK. The exact sequence is proprietary. |
| Antigen Species | Human |
| Species Reactivity | Human, Mouse |
Predicted Cross Reactivity species  Predicted cross-reactivity:
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
| Rat, Xenopus laevis, Pig, Chicken, Bovine |
| Predict Reactivity Note | Rat (99%), Xenopus laevis (87%), Pig (98%), Chicken (91%), Bovine (100%) |
| Conjugation | Unconjugated |