|Applications||ICC/IF, IHC-P, IP, WB|
Not tested in other applications.
|IHC (Formalin-fixed paraffin-embedded sections)||1:100-1:1000*
| Immunoprecipitation||Assay-dependent dilution
*Optimal dilutions/concentrations should be determined by the researcher.
|Predicted Target Size||110 kDa (note)
|Positive Controls||NIH-3T3 , JC , BCL-1 , C2C12 , 293T , A431 , HeLa , HepG2 , A375 , PC-12 , Rat2 |
(Please refer to the vial label for the specific concentration)|
|Purification||Purified by antigen-affinity chromatography.|
|Full Name||CSE1 chromosome segregation 1-like (yeast)|
|Product Description||Rabbit Polyclonal antibody to CSE1L (CSE1 chromosome segregation 1-like (yeast))|
|Background||Proteins that carry a nuclear localization signal (NLS) are transported into the nucleus by the importin-alpha/beta heterodimer. Importin-alpha binds the NLS, while importin-beta mediates translocation through the nuclear pore complex. After translocation, RanGTP binds importin-beta and displaces importin-alpha. Importin-alpha must then be returned to the cytoplasm, leaving the NLS protein behind. The protein encoded by this gene binds strongly to NLS-free importin-alpha, and this binding is released in the cytoplasm by the combined action of RANBP1 and RANGAP1. In addition, the encoded protein may play a role both in apoptosis and in cell proliferation. [provided by RefSeq]|
|Synonyms||CAS antibody, CSE1 antibody, MGC117283 antibody, MGC130036 antibody, MGC130037 antibody, XPO2 antibody, CSE1L antibody, importin-alpha re-exporter antibody, exp2 antibody, chromosome segregation 1-like protein antibody, cellular apoptosis susceptibility protein antibody, exportin-2 antibody, CSE1 chromosome segregation 1-like (yeast) antibody|
|Cellular Localization||Cytoplasm , Nucleus |
|Immunogen||Recombinant protein encompassing a sequence within the center region of human CSE1L. The exact sequence is proprietary.|
|Species Reactivity||Human, Mouse, Rat|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Zebrafish, Pig, Rhesus Monkey, Bovine|
|Predict Reactivity Note||Zebrafish (95%), Pig (100%), Rhesus Monkey (100%), Bovine (100%)|