| Full Name | Kv channel interacting protein 3, calsenilin |
| Background | This gene encodes a member of the family of voltage-gated potassium (Kv) channel-interacting proteins, which belong to the recoverin branch of the EF-hand superfamily. Members of this family are small calcium binding proteins containing EF-hand-like domains. They are integral subunit components of native Kv4 channel complexes that may regulate A-type currents, and hence neuronal excitability, in response to changes in intracellular calcium. The encoded protein also functions as a calcium-regulated transcriptional repressor, and interacts with presenilins. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq] |
| Synonyms | CSEN antibody, DREAM antibody, KCHIP3 antibody, MGC18289 antibody, KCNIP3 antibody, kv channel-interacting protein 3 antibody, potassium channel interacting protein 3 antibody, calsenilin antibody, "calsenilin, presenilin-binding protein, EF hand transcription factor antibody", A-type potassium channel modulatory protein 3 antibody, DRE-antagonist modulator antibody, "Kv channel interacting protein 3, calsenilin antibody" |
| Cellular Localization | Cytoplasm , Cell membrane; Lipid-anchor , Endoplasmic reticulum , Golgi apparatus , Nucleus , Cytoplasm , Cell membrane , Endoplasmic reticulum , Golgi apparatus , Nucleus |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Immunogen | Recombinant protein encompassing a sequence within the center region of human CSEN. The exact sequence is proprietary. |
| Antigen Species | Human |
| Species Reactivity | Human, Mouse |
Predicted Cross Reactivity species  Predicted cross-reactivity:
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
| Rat, Rhesus Monkey, Bovine |
| Predict Reactivity Note | Rat (94%), Rhesus Monkey (98%), Bovine (94%) |
| Conjugation | Unconjugated |