|Full Name||chemokine (C-X-C motif) receptor 2|
|Product Description||Mouse Monoclonal antibody [GT547] to CXCR2 (chemokine (C-X-C motif) receptor 2)|
|Background||The protein encoded by this gene is a member of the G-protein-coupled receptor family. This protein is a receptor for interleukin 8 (IL8). It binds to IL8 with high affinity, and transduces the signal through a G-protein activated second messenger system. This receptor also binds to chemokine (C-X-C motif) ligand 1 (CXCL1/MGSA), a protein with melanoma growth stimulating activity, and has been shown to be a major component required for serum-dependent melanoma cell growth. This receptor mediates neutrophil migration to sites of inflammation. The angiogenic effects of IL8 in intestinal microvascular endothelial cells are found to be mediated by this receptor. Knockout studies in mice suggested that this receptor controls the positioning of oligodendrocyte precursors in developing spinal cord by arresting their migration. This gene, IL8RA, a gene encoding another high affinity IL8 receptor, as well as IL8RBP, a pseudogene of IL8RB, form a gene cluster in a region mapped to chromosome 2q33-q36. [provided by RefSeq]|
|Synonyms||CD182 Antibody, IL8RB Antibody, IL8RA Antibody, IL8R2 Antibody, CXCR2 Antibody, chemokine (C-X-C motif) receptor 2 Antibody, CMKAR2 Antibody, CDw128b Antibody|
|Cellular Localization||Cell membrane |
|Target||IL8 receptor beta|
|Immunogen||Recombinant protein encompassing a sequence within the N-terminus region of human CXCR2. The exact sequence is proprietary.|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Predict Reactivity Note||Chimpanzee (100%)|