|Full Name||cytochrome b5 reductase 3|
|Product Description||Rabbit polyclonal antibody to CYB5R3 (cytochrome b5 reductase 3)|
|Background||This gene encodes cytochrome b5 reductase, which includes a membrane-bound form in somatic cells (anchored in the endoplasmic reticulum, mitochondrial and other membranes) and a soluble form in erythrocytes. The membrane-bound form exists mainly on the cytoplasmic side of the endoplasmic reticulum and functions in desaturation and elongation of fatty acids, in cholesterol biosynthesis, and in drug metabolism. The erythrocyte form is located in a soluble fraction of circulating erythrocytes and is involved in methemoglobin reduction. The membrane-bound form has both membrane-binding and catalytic domains, while the soluble form has only the catalytic domain. These two forms are resulted from alternative splicing of the gene. Mutations in this gene cause methemoglobinemias. [provided by RefSeq]|
|Synonyms||B5R antibody, DIA1 antibody, CYB5R3 antibody, NADH-cytochrome b5 reductase 3 membrane-bound form antibody, NADH-cytochrome b5 reductase 3 soluble form antibody, diaphorase-1 antibody, NADH-cytochrome b5 reductase 3 antibody, cytochrome b5 reductase 3 antibody|
|Cellular Localization||Isoform 1: Endoplasmic reticulum membrane; Lipid-anchor; Cytoplasmic side , Mitochondrion outer membrane; Lipid-anchor; Cytoplasmic side , Isoform 2: Cytoplasm |
|Immunogen||Recombinant protein encompassing a sequence within the center region of human CYB5R3. The exact sequence is proprietary.|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Human, Mouse, Rat, Zebrafish, Dog, Chicken, Rhesus Monkey, Chimpanzee, Bovine|
|Predict Reactivity Note||Human (100%), Mouse (89%), Rat (91%), Zebrafish (82%), Dog (94%), Chicken (80%), Rhesus Monkey (94%), Chimpanzee (97%), Bovine (92%)|