|Full Name||cytochrome P450, family 46, subfamily A, polypeptide 1|
|Product Description||Rabbit Polyclonal antibody to CYP46A1 (cytochrome P450, family 46, subfamily A, polypeptide 1)|
|Background||This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This endoplasmic reticulum protein is expressed in the brain, where it converts cholesterol to 24S-hydroxycholesterol. While cholesterol cannot pass the blood-brain barrier, 24S-hydroxycholesterol can be secreted in the brain into the circulation to be returned to the liver for catabolism. [provided by RefSeq]|
|Synonyms||CP46 antibody, CYP46 antibody, CYP46A1 antibody, cytochrome P450 46A1 antibody, cholesterol 24-hydroxylase antibody, CH24H antibody, "cytochrome P450, subfamily 46 (cholesterol 24-hydroxylase) antibody", "cytochrome P450, family 46, subfamily A, polypeptide 1 antibody"|
|Cellular Localization||Endoplasmic reticulum membrane , Microsome membrane |
|Immunogen||Recombinant protein encompassing a sequence within the center region of human CYP46A1. The exact sequence is proprietary.|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Human, Rat, Bovine|
|Predict Reactivity Note||Human (100%), Rat (91%), Bovine (89%)|