| Catalog Number | GTX36254 |
| Product Name | CaMKII (oxidized) antibody |
| Synonyms | CAMK, CAMK-II, CAMKG |
| Product Description | Rabbit polyclonal antibody against the oxidized M281/282 form of CAMKII |
| Background | Calcium/calmodulin-dependent protein kinase II (CaMKII) couples increases in Ca2+ to fundamental responses in excitable cells including activation of ion channels, gene transcription and apoptosis. CaMKII is activated by angiotensin II-induced oxidation, which leads to apoptosis in cardiomyocytes. CaMKII activity is also enhanced by pro-oxidant conditions, and the oxidation of paired regulatory domain methionine residues sustains CaMKII activity in the absence of Ca2+/CaM. |
| Specificity | Mouse |
| Host | Rabbit |
| Clonality | Polyclonal |
| Species Reactivity | Mouse |
| Applications | ICC/IF, IHC (Frozen sections), IHC (Formalin-fixed paraffin-embedded sections), Western blot. The usefulness of this product in other applications has not been determined. |
| Application Note | For WB, use at a dilution of 1:1,000, For IF, use at a dilution of 1:50 with paraffin-embedded sections and 1:100 with frozen sections. |
| Form Supplied | Liquid |
| Storage Instruction | Keep as concentrated solution. Aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
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