|Full Name||calcium-sensing receptor|
|Product Description||Rabbit polyclonal antibody to Calcium Sensing Receptor (calcium-sensing receptor (hypocalciuric hypercalcemia 1, severe neonatal hyperparathyroidism))|
|Background||The protein encoded by this gene is a G protein-coupled receptor that is expressed in the parathyroid hormone (PTH)-producing chief cells of the parathyroid gland, and the cells lining the kidney tubule. It senses small changes in circulating calcium concentration and couples this information to intracellular signaling pathways that modify PTH secretion or renal cation handling, thus this protein plays an essential role in maintaining mineral ion homeostasis. Mutations in this gene cause familial hypocalciuric hypercalcemia, familial, isolated hypoparathyroidism, and neonatal severe primary hyperparathyroidism. [provided by RefSeq]|
|Synonyms||CAR antibody, EIG8 antibody, FHH antibody, FIH antibody, GPRC2A antibody, HHC antibody, HHC1 antibody, MGC138441 antibody, NSHPT antibody, PCAR1 antibody, CASR antibody, parathyroid cell calcium-sensing receptor antibody, parathyroid Ca(2+)-sensing receptor 1 antibody, extracellular calcium-sensing receptor antibody, calcium-sensing receptor antibody|
|Cellular Localization||Cell membrane |
|Target||Calcium Sensing Receptor|
|Immunogen||Recombinant protein encompassing a sequence within the center region of human Calcium Sensing Receptor. The exact sequence is proprietary.|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Mouse, Rat, Dog, Cat, Pig, Bovine|
|Predict Reactivity Note||Mouse (93%), Rat (94%), Dog (95%), Cat (95%), Pig (95%), Bovine (95%)|