Caspase 1 antibody [N1N3]
|Applications||ICC/IF, IHC-P, WB|
Not tested in other applications.
|IHC (Formalin-fixed paraffin-embedded sections)||1:100-1:1000*
*Optimal dilutions/concentrations should be determined by the researcher.
|Predicted Target Size||45 kDa (note)
|Positive Controls||A549 , HeLa , HepG2 , HCT116 , THP-1 conditioned medium (500 ng/ml LPS treatment for 4 hr and 1 mM ATP treatment for 1.5hr)|
(Please refer to the vial label for the specific concentration)|
|Purification||Purified by antigen-affinity chromatography.|
|Full Name||caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase)|
|Product Description||Rabbit Polyclonal antibody to Caspase 1 alpha (caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase))|
|Background||This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce 2 subunits, large and small, that dimerize to form the active enzyme. This gene was identified by its ability to proteolytically cleave and activate the inactive precursor of interleukin-1, a cytokine involved in the processes such as inflammation, septic shock, and wound healing. This gene has been shown to induce cell apoptosis and may function in various developmental stages. Studies of a similar gene in mouse suggest a role in the pathogenesis of Huntington disease. Alternative splicing of this gene results in five transcript variants encoding distinct isoforms. [provided by RefSeq]|
|Synonyms||ICE antibody, IL1BC antibody, P45 antibody, CASP1 antibody, CASP1 nirs variant 1 antibody, IL-1BC antibody, caspase-1 antibody, interleukin 1-B converting enzyme antibody, IL1B-convertase antibody, IL-1 beta-converting enzyme antibody, "caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase) antibody"|
|Immunogen||Recombinant protein encompassing a sequence within the center region of human Caspase 1. The exact sequence is proprietary.|