|Full Name||caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase)|
|Product Description||Rabbit Polyclonal antibody to Caspase 1 p10 subunit (caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase))|
|Background||This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce 2 subunits, large and small, that dimerize to form the active enzyme. This gene was identified by its ability to proteolytically cleave and activate the inactive precursor of interleukin-1, a cytokine involved in the processes such as inflammation, septic shock, and wound healing. This gene has been shown to induce cell apoptosis and may function in various developmental stages. Studies of a similar gene in mouse suggest a role in the pathogenesis of Huntington disease. Alternative splicing of this gene results in five transcript variants encoding distinct isoforms. [provided by RefSeq]|
|Synonyms||ICE antibody, IL1BC antibody, P45 antibody, CASP1 antibody, CASP1 nirs variant 1 antibody, IL-1BC antibody, caspase-1 antibody, interleukin 1-B converting enzyme antibody, IL1B-convertase antibody, IL-1 beta-converting enzyme antibody, "caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase) antibody"|
|Immunogen||Recombinant protein encompassing a sequence within the C-terminus region of human Caspase 1 p10 subunit. The exact sequence is proprietary.|
|Species Reactivity||Human, Mouse|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Predict Reactivity Note||Rat (83%), Pig (81%)|