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Catalog Number
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GTX123679
(
0
)
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Product Name
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Caspase 7 antibody
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| Applications | IHC-P, WB |
| Application Note |
| Suggested dilution | Reference |
| IHC (Formalin-fixed paraffin-embedded sections) | 1:100-1:1000* |
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| Western Blot (WB) | 1:500-1:3000* |
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Not tested in other applications.
*Optimal dilutions/concentrations should be determined by the researcher.
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| Predicted Target Size | 34 kDa (note)
 (8)
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| Positive Controls | 293T , A431 , HeLa , HepG2 , Jurakt , Jurakt (10 μM etoposide treatment for 24 hr) |
| Form Supplied | Liquid |
| Concentration | 0.93
mg/ml
(Please refer to the vial label for the specific concentration) |
| Purification | Purified by antigen-affinity chromatography. |
| Full Name | caspase 7, apoptosis-related cysteine peptidase |
| Product Description | Rabbit Polyclonal antibody to Caspase 7 (caspase 7, apoptosis-related cysteine peptidase) |
| Background | This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. The precursor of this caspase is cleaved by caspase 3 and 10. It is activated upon cell death stimuli and induces apoptosis. Alternative splicing results in four transcript variants, encoding three distinct isoforms. [provided by RefSeq] |
| Synonyms | CMH-1 antibody, ICE-LAP3 antibody, MCH3 antibody, CASP7 antibody, "caspase 7, apoptosis-related cysteine protease antibody", CASP-7 antibody, Lice2 alpha/beta/gamma antibody, caspase 7 isoform delta antibody, apoptotic protease MCH-3 antibody, caspase-7 antibody, ICE-like apoptotic protease 3 antibody, "caspase 7, apoptosis-related cysteine peptidase antibody" |
| Cellular Localization | Cytoplasm |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Immunogen | Recombinant protein encompassing a sequence within the C-terminus region of human Caspase 7. The exact sequence is proprietary. |
| Antigen Species | Human |
| Species Reactivity | Human |
Predicted Cross Reactivity species  Predicted cross-reactivity:
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
| Mouse, Rat, Zebrafish, Xenopus laevis |
| Predict Reactivity Note | Mouse (91%), Rat (91%), Zebrafish (82%), Xenopus laevis (81%) |
| Conjugation | Unconjugated |