|Full Name||cathepsin B|
|Product Description||Rabbit Polyclonal antibody to Cathepsin B (cathepsin B)|
|Background||The protein encoded by this gene is a lysosomal cysteine proteinase composed of a dimer of disulfide-linked heavy and light chains, both produced from a single protein precursor. It is also known as amyloid precursor protein secretase and is involved in the proteolytic processing of amyloid precursor protein (APP). Incomplete proteolytic processing of APP has been suggested to be a causative factor in Alzheimer disease, the most common cause of dementia. Overexpression of the encoded protein, which is a member of the peptidase C1 family, has been associated with esophageal adenocarcinoma and other tumors. At least five transcript variants encoding the same protein have been found for this gene. [provided by RefSeq]|
|Synonyms||APPS antibody, CPSB antibody, CTSB antibody, cysteine protease antibody, cathepsin B1 antibody, amyloid precursor protein secretase antibody, APP secretase antibody, cathepsin B antibody|
|Cellular Localization||Lysosome , Melanosome |
|Immunogen||Recombinant protein encompassing a sequence within the center region of human Cathepsin B. The exact sequence is proprietary.|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Human, Mouse, Rat, Xenopus laevis, Pig, Chicken, Sheep, Rhesus Monkey, Bovine|
|Predict Reactivity Note||Human (100%), Mouse (83%), Rat (83%), Xenopus laevis (82%), Pig (87%), Chicken (84%), Sheep (88%), Rhesus Monkey (98%), Bovine (88%)|