|Full Name||calcium channel, voltage-dependent, beta 4 subunit|
|Product Description||Rabbit Polyclonal antibody to Cav beta 4|
|Background||This gene encodes a member of the beta subunit family of voltage-dependent calcium channel complex proteins. Calcium channels mediate the influx of calcium ions into the cell upon membrane polarization and consist of a complex of alpha-1, alpha-2/delta, beta, and gamma subunits in a 1:1:1:1 ratio. Various versions of each of these subunits exist, either expressed from similar genes or the result of alternative splicing. The protein encoded by this locus plays an important role in calcium channel function by modulating G protein inhibition, increasing peak calcium current, controlling the alpha-1 subunit membrane targeting and shifting the voltage dependence of activation and inactivation. Certain mutations in this gene have been associated with idiopathic generalized epilepsy (IGE) and juvenile myoclonic epilepsy (JME). Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq]|
|Synonyms||CAB4 antibody, CACNLB4 antibody, EA5 antibody, EIG9 antibody, EJM antibody, EJM4 antibody, EJM6 antibody, CACNB4 antibody, "dihydropyridine-sensitive L-type, calcium channel beta-4 subunit antibody", calcium channel voltage-dependent subunit beta 4 antibody, voltage-dependent L-type calcium channel subunit beta-4 antibody, "calcium channel, voltage-dependent, beta 4 subunit antibody"|
|Target||Cav beta 4|
|Immunogen||Carrier-protein conjugated synthetic peptide encompassing a sequence within the C-terminus region of human CACNB4. The exact sequence is proprietary.|
|Species Reactivity||Human, Mouse|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Pig, Chicken, Rhesus Monkey, Bovine|
|Predict Reactivity Note||Pig (100%), Chicken (100%), Rhesus Monkey (100%), Bovine (100%)|