Caveolin 1 antibody [N1N3]
|Applications||ICC/IF, IHC, IHC-P, IP, WB|
Not tested in other applications.
| Immunohistochemistry||Assay-dependent dilution
|IHC (Formalin-fixed paraffin-embedded sections)||1:100-1:1000*
*Optimal dilutions/concentrations should be determined by the researcher.
|Predicted Target Size||20 kDa (note)
|Positive Controls||A431 , H1299 , HeLa , *A549 , *A7 , Mouse lung |
(Please refer to the vial label for the specific concentration)|
|Purification||Purified by antigen-affinity chromatography.|
|Full Name||caveolin 1, caveolae protein, 22kDa|
|Product Description||Rabbit polyclonal antibody to Caveolin 1 (caveolin 1, caveolae protein, 22kDa)|
|Background||The scaffolding protein encoded by this gene is the main component of the caveolae plasma membranes found in most cell types. The protein links integrin subunits to the tyrosine kinase FYN, an initiating step in coupling integrins to the Ras-ERK pathway and promoting cell cycle progression. The gene is a tumor suppressor gene candidate and a negative regulator of the Ras-p42/44 MAP kinase cascade. CAV1 and CAV2 are located next to each other on chromosome 7 and express colocalizing proteins that form a stable hetero-oligomeric complex. By using alternative initiation codons in the same reading frame, two isoforms (alpha and beta) are encoded by a single transcript from this gene. [provided by RefSeq]|
|Synonyms||BSCL3 antibody, CGL3 antibody, MSTP085 antibody, VIP21 antibody, CAV1 antibody, cell growth-inhibiting protein 32 antibody, caveolin-1 antibody, "caveolin 1, caveolae protein, 22kDa antibody"|
|Cellular Localization||Golgi apparatus membrane , Cell membrane , Membrane , caveola |
|Immunogen||Carrier-protein conjugated synthetic peptide encompassing a sequence within the N-terminus region of human Caveolin 1. The exact sequence is proprietary.|
|Species Reactivity||Human, Mouse, Rat|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Rhesus Monkey, Chimpanzee|
|Predict Reactivity Note||Rhesus Monkey (100%), Chimpanzee (100%)|