|Full Name||Cas-Br-M (murine) ecotropic retroviral transforming sequence b|
|Product Description||Rabbit polyclonal antibody to Cbl-b (Cas-Br-M (murine) ecotropic retroviral transforming sequence b)|
|Background||E3 ubiquitin-protein ligase which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and transfers it to substrates, generally promoting their degradation by the proteasome. Negatively regulates TCR (T-cell receptor), BCR (B-cell receptor) and FCER1 (high affinity immunoglobulin epsilon receptor) signal transduction pathways. In naive T-cells, inhibits VAV1 activation upon TCR engagement and imposes a requirement for CD28 costimulation for proliferation and IL-2 production. Also acts by promoting PIK3R1/p85 ubiquitination, which impairs its recruitment to the TCR and subsequent activation. In activated T-cells, inhibits PLCG1 activation and calcium mobilization upon restimulation and promotes anergy. In B-cells, acts by ubiquitinating SYK and promoting its proteasomal degradation. May also be involved in EGFR ubiquitination and internalization.|
|Synonyms||DKFZp686J10223 antibody, DKFZp779A0729 antibody, DKFZp779F1443 antibody, FLJ36865 antibody, FLJ41152 antibody, RNF56 antibody, CBLB antibody, E3 ubiquitin-protein ligase CBL-B antibody, signal transduction protein CBL-B antibody, casitas B-lineage lymphoma proto-oncogene b antibody, Cas-Br-M (murine) ectropic retroviral transforming sequence b antibody, RING finger protein 56 antibody, SH3-binding protein CBL-B antibody, Cas-Br-M (murine) ecotropic retroviral transforming sequence b antibody|
|Immunogen||Recombinant protein encompassing a sequence within the C-terminus region of human Cbl-b. The exact sequence is proprietary.|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Mouse, Rat, Bovine|
|Predict Reactivity Note||Mouse (82%), Rat (84%), Bovine (95%)|