Not tested in other applications.
*Optimal dilutions/concentrations should be determined by the researcher.
|Predicted Target Size||63 kDa (note)
|Positive Controls||Jurkat , Neuro2A , GL261 , C8D30 , BCL-1 , Raw264.7 , C2C12 , Rat2|
(Please refer to the vial label for the specific concentration)|
|Purification||Purified by antigen-affinity chromatography.|
|Full Name||cell division cycle 6 homolog (S. cerevisiae)|
|Product Description||Rabbit Polyclonal antibody to CDC6 (cell division cycle 6 homolog (S. cerevisiae))|
|Background||The protein encoded by this gene is highly similar to Saccharomyces cerevisiae Cdc6, a protein essential for the initiation of DNA replication. This protein functions as a regulator at the early steps of DNA replication. It localizes in cell nucleus during cell cyle G1, but translocates to the cytoplasm at the start of S phase. The subcellular translocation of this protein during cell cyle is regulated through its phosphorylation by Cdks. Transcription of this protein was reported to be regulated in response to mitogenic signals through transcriptional control mechanism involving E2F proteins. [provided by RefSeq]|
|Synonyms||CDC18L antibody, HsCDC18 antibody, HsCDC6 antibody, CDC6 antibody, p62(cdc6) antibody, cdc18-related protein antibody, CDC6-related protein antibody, CDC6 cell division cycle 6 homolog antibody, cell division control protein 6 homolog antibody, cell division cycle 6 homolog (S. cerevisiae) antibody|
|Cellular Localization||Nucleus , Cytoplasm|
|Immunogen||Recombinant protein encompassing a sequence within the center region of human CDC6. The exact sequence is proprietary.|
|Species Reactivity||Human, Mouse, Rat|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Predict Reactivity Note||Bovine (89%)|