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1 .GTX32379 Chk2 (phospho Ser516) antibody

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Chk2 (phospho Ser516) antibody


  • Host / ClonalityRabbit Polyclonal
  • ApplicationsWB
  • Species reactivityHuman
Cat No: GTX32379
Package Price Qty
100 μlUSD 319.00
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  • Anti-Chk2 (phospho Ser516) antibody used in Western Blot (WB). GTX32379
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  • Datasheet
  • Application Information: Chk2 (phospho Ser516) antibody

Catalog Number GTX32379
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Product Name Chk2 (phospho Ser516) antibody
See all Chk2 products
ApplicationsWB
Application NoteWB: 1:500 - 1:1000
Form SuppliedLiquid
PurificationThe antibody was purified by immunogen affinity chromatography.

  • Specifications: Chk2 (phospho Ser516) antibody

Full Namecheckpoint kinase 2
BackgroundIn response to DNA damage and replication blocks, cell cycle progression is halted through the control of critical cell cycle regulators. The protein encoded by this gene is a cell cycle checkpoint regulator and putative tumor suppressor. It contains a forkhead-associated protein interaction domain essential for activation in response to DNA damage and is rapidly phosphorylated in response to replication blocks and DNA damage. When activated, the encoded protein is known to inhibit CDC25C phosphatase, preventing entry into mitosis, and has been shown to stabilize the tumor suppressor protein p53, leading to cell cycle arrest in G1. In addition, this protein interacts with and phosphorylates BRCA1, allowing BRCA1 to restore survival after DNA damage. Mutations in this gene have been linked with Li-Fraumeni syndrome, a highly penetrant familial cancer phenotype usually associated with inherited mutations in TP53. Also, mutations in this gene are thought to confer a predisposition to sarc
SynonymsCDS1 Antibody , LFS2 Antibody , hCds1 Antibody , CHK2 Antibody , CHEK2 Antibody , PP1425 Antibody , checkpoint kinase 2 Antibody , RAD53 Antibody , HuCds1 Antibody
SpecificityRecognizes endogenous levels of CHK2 (pS516) protein.
HostRabbit
ClonalityPolyclonal
IsotypeIgG
ImmunogenKLH-conjugated synthetic peptide encompassing a sequence within the C-term region of human CHK2 (pS516). The exact sequence is proprietary.
Antigen SpeciesHuman
Species ReactivityHuman
ConjugationUnconjugated

  • Storage Conditions: Chk2 (phospho Ser516) antibody

Storage BufferLiquid in 0.42% Potassium phosphate; 0.87% Sodium chloride; pH 7.3; 30% glycerol; and 0.01% sodium azide.
Storage InstructionShipped at 4 °C. Upon delivery aliquot and store at -20 °C for one year. Avoid freeze/thaw cycles.
NotesFor In vitro laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
ResearchArea
  • Cancer > Apoptosis > Induction > DNA damage sensors
  • Cancer > Type of cancer > Brain > Glioma
  • Cancer > Type of cancer > Brain > Meningeal
  • Cancer > Type of cancer > Breast > Ductal
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Chk2 (phospho Ser516) antibody validated data
  • Anti-Chk2 (phospho Ser516) antibody used in Western Blot (WB). GTX32379
    • GTX32379 WB Image
      Western blot analysis of CHK2 (pS516) expression in HeLa (A) whole cell lysates.
      Top
  • Anti-Chk2 (phospho Ser516) antibody used in Western Blot (WB). GTX32379
    • GTX32379 WB Image
      Western blot analysis of CHK2 (pS516) expression in HeLa (A) whole cell lysates.
      Top
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