| Full Name | checkpoint kinase 2 |
| Product Description | Rabbit Polyclonal antibody to Chk2 (phospho Ser516) |
| Background | In response to DNA damage and replication blocks, cell cycle progression is halted through the control of critical cell cycle regulators. The protein encoded by this gene is a cell cycle checkpoint regulator and putative tumor suppressor. It contains a forkhead-associated protein interaction domain essential for activation in response to DNA damage and is rapidly phosphorylated in response to replication blocks and DNA damage. When activated, the encoded protein is known to inhibit CDC25C phosphatase, preventing entry into mitosis, and has been shown to stabilize the tumor suppressor protein p53, leading to cell cycle arrest in G1. In addition, this protein interacts with and phosphorylates BRCA1, allowing BRCA1 to restore survival after DNA damage. Mutations in this gene have been linked with Li-Fraumeni syndrome, a highly penetrant familial cancer phenotype usually associated with inherited mutations in TP53. Also, mutations in this gene are thought to confer a predisposition to sarc |
| Synonyms | CDS1 Antibody , LFS2 Antibody , hCds1 Antibody , CHK2 Antibody , CHEK2 Antibody , PP1425 Antibody , checkpoint kinase 2 Antibody , RAD53 Antibody , HuCds1 Antibody |
| Specificity | Recognizes endogenous levels of CHK2 (pS516) protein. |
| Host | Rabbit |
| Clonality | Polyclonal |
| Target | Chk2 (phospho Ser516) |
| Isotype | IgG |
| Immunogen | KLH-conjugated synthetic peptide encompassing a sequence within the C-term region of human CHK2 (pS516). The exact sequence is proprietary. |
| Antigen Species | Human |
| Species Reactivity | Human |
| Conjugation | Unconjugated |