|Full Name||claudin 1|
|Product Description||Rabbit Polyclonal antibody to Claudin 1|
|Background||Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. These junctions are comprised of sets of continuous networking strands in the outwardly facing cytoplasmic leaflet, with complementary grooves in the inwardly facing extracytoplasmic leaflet. The protein encoded by this gene, a member of the claudin family, is an integral membrane protein and a component of tight junction strands. Loss of function mutations result in neonatal ichthyosis-sclerosing cholangitis syndrome. [provided by RefSeq]|
|Synonyms||CLD1 antibody, ILVASC antibody, SEMP1 antibody, CLDN1 antibody, claudin-1 antibody, senescence-associated epithelial membrane protein 1 antibody, claudin 1 antibody|
|Cellular Localization||Cell junction , tight junction , Cell membrane; Multi-pass membrane protein , Cell junction , tight junction , Cell membrane |
|Immunogen||Carrier-protein conjugated synthetic peptide encompassing a sequence within the C-terminus region of human claudin 1. The exact sequence is proprietary.|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Human, Sheep, Rhesus Monkey, Bovine|
|Predict Reactivity Note||Human (100%), Sheep (100%), Rhesus Monkey (100%), Bovine (100%)|