|Full Name||collagen, type II, alpha 1|
|Product Description||Rabbit Polyclonal antibody to Collagen II|
|Background||This antibody is well suited to detect extracellular matrix proteins in normal as well as disease state tissues. Disruption of tissue organization is the hallmark of neoplasia. Malignant lesions can be distinguished from benign by examining the breakdown of basement membranes and loss of 3-dimensional architecture. Malignant cells are presumed to use matrix metalloproteases to degrade barriers created by the extracellular matrix, which then allows metastasis to occur. Collagenases, stomelysins and gelatinases can collectively degrade all of the various components of the extracellular matrix, including fibrillar and non-fibrillar collagens and basement membrane glycoproteins|
|Synonyms||COL2A1 Antibody , COL11A3 Antibody , ANFH Antibody , SEDC Antibody , AOM Antibody|
|Cellular Localization||Extracellular matrix.|
|Specificity||Anti-Collagen Type II has been prepared by immunoaffinity chromatography using immobilized antigens followed by extensive cross-adsorption against other collagens, human serum proteins and non-collagen extracellular matrix proteins to remove any unwanted|
|Immunogen||Collagen Type II from adult human knee cartilage and bovine nasal cartilage.|
|Antigen Species||Human, Bovine|
|Species Reactivity||Human, Bovine|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.