|Full Name||collagen, type IV, alpha 4|
|Product Description||Rabbit polyclonal antibody to Collagen alpha-4(IV) (collagen, type IV, alpha 4)|
|Background||This gene encodes one of the six subunits of type IV collagen, the major structural component of basement membranes. This particular collagen IV subunit, however, is only found in a subset of basement membranes. Like the other members of the type IV collagen gene family, this gene is organized in a head-to-head conformation with another type IV collagen gene so that each gene pair shares a common promoter. Mutations in this gene are associated with type II autosomal recessive Alport syndrome (hereditary glomerulonephropathy) and with familial benign hematuria (thin basement membrane disease). Two transcripts, differing only in their transcription start sites, have been identified for this gene and, as is common for collagen genes, multiple polyadenylation sites are found in the 3' UTR. [provided by RefSeq]|
|Synonyms||CA44 antibody, COL4A4 antibody, collagen alpha-4(IV) chain antibody, "collagen of basement membrane, alpha-4 chain antibody", "Collagen IV, alpha-4 polypeptide antibody", "collagen, type IV, alpha 4 antibody"|
|Cellular Localization||Secreted , extracellular space , extracellular matrix , basement membrane |
|Immunogen||Recombinant protein encompassing a sequence within the C-terminus region of human Collagen alpha-4(IV). The exact sequence is proprietary.|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Human, Mouse, Dog|
|Predict Reactivity Note||Human (100%), Mouse (94%), Dog (91%)|