|Full Name||creatine kinase, mitochondrial 1B|
|Product Description||Rabbit Polyclonal antibody to Creatine kinase 1B (creatine kinase, mitochondrial 1B)|
|Background||Mitochondrial creatine (MtCK) kinase is responsible for the transfer of high energy phosphate from mitochondria to the cytosolic carrier, creatine. It belongs to the creatine kinase isoenzyme family. It exists as two isoenzymes, sarcomeric MtCK and ubiquitous MtCK, encoded by separate genes. Mitochondrial creatine kinase occurs in two different oligomeric forms: dimers and octamers, in contrast to the exclusively dimeric cytosolic creatine kinase isoenzymes. Many malignant cancers with poor prognosis have shown overexpression of ubiquitous mitochondrial creatine kinase; this may be related to high energy turnover and failure to eliminate cancer cells via apoptosis. Ubiquitous mitochondrial creatine kinase has 80% homology with the coding exons of sarcomeric mitochondrial creatine kinase. Two genes located near each other on chromosome 15 have been identified which encode identical mitochondrial creatine kinase proteins. [provided by RefSeq]|
|Synonyms||CKMT antibody, CKMT1 antibody, CKMT1A antibody, UMTCK antibody, CKMT1B antibody, "creatine kinase U-type, mitochondrial antibody", "creatine kinase, mitochondrial 1 (ubiquitous) antibody", ubiquitous mitochondrial creatine kinase antibody, U-MtCK antibody, acidic-type mitochondrial creatine kinase antibody, mia-CK antibody, "creatine kinase, mitochondrial 1B antibody"|
|Cellular Localization||Mitochondrion inner membrane; Peripheral membrane protein; Intermembrane side |
|Immunogen||Recombinant protein encompassing a sequence within the center region of human Creatine kinase 1B. The exact sequence is proprietary.|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Rat, Xenopus laevis, Rabbit, Bovine|
|Predict Reactivity Note||Rat (98%), Xenopus laevis (88%), Rabbit (99%), Bovine (98%)|