|Full Name||NLR family, pyrin domain containing 3|
|Product Description||Rabbit polyclonal antibody to NLRP3 (NLR family, pyrin domain containing 3)|
|Background||This gene encodes a pyrin-like protein containing a pyrin domain, a nucleotide-binding site (NBS) domain, and a leucine-rich repeat (LRR) motif. This protein interacts with the apoptosis-associated speck-like protein PYCARD/ASC, which contains a caspase recruitment domain, and is a member of the NALP3 inflammasome complex. This complex functions as an upstream activator of NF-kappaB signaling, and it plays a role in the regulation of inflammation, the immune response, and apoptosis. Mutations in this gene are associated with familial cold autoinflammatory syndrome (FCAS), Muckle-Wells syndrome (MWS), chronic infantile neurological cutaneous and articular (CINCA) syndrome, and neonatal-onset multisystem inflammatory disease (NOMID). Multiple alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene. Alternative 5' UTR structures are suggested by available data; however, insufficient evidence is available to determine if all of the represented 5' UTR splice patterns are biologically valid. [provided by RefSeq]|
|Synonyms||AGTAVPRL antibody, AII antibody, AII/AVP antibody, AVP antibody, C1orf7 antibody, CIAS1 antibody, CLR1.1 antibody, FCAS antibody, FCU antibody, FLJ95925 antibody, MWS antibody, NALP3 antibody, PYPAF1 antibody, NLRP3 antibody, cold autoinflammatory syndrome 1 protein antibody, "NACHT, LRR and PYD containing protein 3 antibody", PYRIN-containing APAF1-like protein 1 antibody, cryopyrin antibody, "NACHT domain-, leucine-rich repeat-, and PYD-containing protein 3 antibody", "nucleotide-binding oligomerization domain, leucine rich repeat and pyrin domain containing 3 antibody", "NACHT, LRR and PYD domains-containing protein 3 antibody", caterpiller protein 1.1 antibody, "NLR family, pyrin domain containing 3 antibody"|
|Immunogen||Carrier-protein conjugated synthetic peptide encompassing a sequence within the C-terminus region of human Cryopyrin. The exact sequence is proprietary.|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Mouse, Rat, Pig, Rhesus Monkey, Bovine|
|Predict Reactivity Note||Mouse (85%), Rat (92%), Pig (92%), Rhesus Monkey (92%), Bovine (92%)|