|Full Name||cyclin D3|
|Product Description||Rabbit polyclonal antibody to cyclin-D3 (cyclin D3)|
|Background||The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activtiy is required for cell cycle G1/S transition. This protein has been shown to interact with and be involved in the phosphorylation of tumor suppressor protein Rb. The CDK4 activity associated with this cyclin was reported to be necessary for cell cycle progression through G2 phase into mitosis after UV radiation. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq]|
|Synonyms||CCND3 antibody, G1/S-specific cyclin-D3 antibody, G1/S-specific cyclin D3 antibody, D3-type cyclin antibody, cyclin D3 antibody|
|Cellular Localization||Cytoplasm , Nucleus|
|Immunogen||Recombinant protein encompassing a sequence within the center region of human Cyclin D3. The exact sequence is proprietary.|
|Species Reactivity||Human, Mouse|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Rat, Pig, Sheep, Rhesus Monkey, Bovine|
|Predict Reactivity Note||Rat (93%), Pig (96%), Sheep (96%), Rhesus Monkey (98%), Bovine (96%)|