|Full Name||cystatin B (stefin B)|
|Product Description||Rabbit Polyclonal antibody to Cystatin B (cystatin B (stefin B))|
|Background||The cystatin superfamily encompasses proteins that contain multiple cystatin-like sequences. Some of the members are active cysteine protease inhibitors, while others have lost or perhaps never acquired this inhibitory activity. There are three inhibitory families in the superfamily, including the type 1 cystatins (stefins), type 2 cystatins and kininogens. This gene encodes a stefin that functions as an intracellular thiol protease inhibitor. The protein is able to form a dimer stabilized by noncovalent forces, inhibiting papain and cathepsins l, h and b. The protein is thought to play a role in protecting against the proteases leaking from lysosomes. Evidence indicates that mutations in this gene are responsible for the primary defects in patients with progressive myoclonic epilepsy (EPM1). [provided by RefSeq]|
|Synonyms||CST6 antibody, EPM1 antibody, PME antibody, STFB antibody, CSTB antibody, stefin-B antibody, CPI-B antibody, cystatin-B antibody, stefin B antibody, liver thiol proteinase inhibitor antibody, cystatin B (stefin B) antibody|
|Cellular Localization||Cytoplasm , Nucleus |
|Immunogen||Recombinant protein encompassing a sequence within the center region of human Cystatin B. The exact sequence is proprietary.|
|Species Reactivity||Human, Mouse|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Pig, Rhesus Monkey, Chimpanzee|
|Predict Reactivity Note||Pig (81%), Rhesus Monkey (95%), Chimpanzee (98%)|