Cytochrome P450 17A1 antibody [N3C2], Internal
Not tested in other applications.
*Optimal dilutions/concentrations should be determined by the researcher.
|Predicted Target Size||57 kDa (note)
|Positive Controls||A431 , H1299 , HeLa , HepG2 , Molt-4 , Raji|
(Please refer to the vial label for the specific concentration)|
|Purification||Purified by antigen-affinity chromatography.|
|Full Name||cytochrome P450, family 17, subfamily A, polypeptide 1|
|Product Description||Rabbit polyclonal antibody to Cytochrome P450 17A1 (cytochrome P450, family 17, subfamily A, polypeptide 1)|
|Background||This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum. It has both 17alpha-hydroxylase and 17,20-lyase activities and is a key enzyme in the steroidogenic pathway that produces progestins, mineralocorticoids, glucocorticoids, androgens, and estrogens. Mutations in this gene are associated with isolated steroid-17 alpha-hydroxylase deficiency, 17-alpha-hydroxylase/17,20-lyase deficiency, pseudohermaphroditism, and adrenal hyperplasia. [provided by RefSeq]|
|Synonyms||CPT7 antibody, CYP17 antibody, P450C17 antibody, S17AH antibody, CYP17A1 antibody, cytochrome P450c17 antibody, cytochrome P450 17A1 antibody, cytochrome P450-C17 antibody, "cytochrome P450, subfamily XVII (steroid 17-alpha-hydroxylase), adrenal hyperplasia antibody", "steroid 17-alpha-hydroxylase/17,20 lyase antibody", CYPXVII antibody, cytochrome p450 XVIIA1 antibody, steroid 17-alpha-monooxygenase antibody, "cytochrome P450, family 17, subfamily A, polypeptide 1 antibody"|
|Cellular Localization||Membrane , Membrane; Single-pass membrane protein , Membrane , Membrane |
|Target||Cytochrome P450 17A1|
|Immunogen||Recombinant protein encompassing a sequence within the center region of human Cytochrome P450 17A1. The exact sequence is proprietary.|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Cat, Rhesus Monkey, Chimpanzee|
|Predict Reactivity Note||Cat (81%), Rhesus Monkey (95%), Chimpanzee (99%)|