|Full Name||dystroglycan 1 (dystrophin-associated glycoprotein 1)|
|Product Description||Goat polyclonal antibody to DAG1|
|Background||The dystroglycan complex is involved in a number of processes including laminin and basement membrane assembly, sacrolemmal stability, cell survival, peripheral nerve myelination, nodal structure, cell migration, and epithelial polarization. Alpha-dystroglycan is an extracellular peripheral glycoprotein that acts as a receptor for both extracellular matrix proteins containing laminin-G domains, and for certain adenoviruses. Receptor for laminin-2 (LAMA2) and agrin in peripheral nerve Schwann cells. Also acts as a receptor for M.leprae in peripheral nerve Schwann cells but only in the presence of the G-domain of LAMA2, and for lymphocytic choriomeningitis virus, Old World Lassa fever virus, and clade C New World arenaviruses. Beta-dystroglycan is a transmembrane protein that plays important roles in connecting the extracellular matrix to the cytoskeleton. Acts as a cell adhesion receptor in both muscle and non-muscle tissues. Receptor for both DMD and UTRN and, through these interactions, scaffolds axin to the cytoskeleton. Also functions in cell adhesion-mediated signaling and implicated in cell polarity. |
|Synonyms||betadystroglycan, dystroglycan1 (dystrophinassociated glycoprotein1), dystroglycan 1 (dystrophinassociated glycoprotein 1), dystroglycan 1 (dystrophin-associated glycoprotein 1), AGRNR, A3a, alpha-dystroglycan, alphadystroglycan, beta-dystroglycan, 156DAG, DAG1, dystroglycan 1, dystroglycan1, DAG, beta dystroglycan, alpha dystroglycan|
|Cellular Localization||The monomeric form translocates to the nucleus via the action of importins and depends on RAN. Nuclear transport is inhibited by Tyr-892 phosphorylation. In skeletal muscle, this phosphorylated form locates to a vesicular internal membrane compartment. In|
|Specificity||This antibody is specific for DAG1.|
|Species Reactivity||Human, Mouse, Rat|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.