|Full Name||dystroglycan 1 (dystrophin-associated glycoprotein 1)|
|Product Description||Rabbit Polyclonal antibody to beta dystroglycan (dystroglycan 1 (dystrophin-associated glycoprotein 1))|
|Background||Dystroglycan is a laminin binding component of the dystrophin-glycoprotein complex which provides a linkage between the subsarcolemmal cytoskeleton and the extracellular matrix. Dystroglycan 1 is a candidate gene for the site of the mutation in autosomal recessive muscular dystrophies. The dramatic reduction of dystroglycan 1 in Duchenne muscular dystrophy leads to a loss of linkage between the sarcolemma and extracellular matrix, rendering muscle fibers more susceptible to necrosis. Dystroglycan also functions as dual receptor for agrin and laminin-2 in the Schwann cell membrane. The muscle and nonmuscle isoforms of dystroglycan differ by carbohydrate moieties but not protein sequence. [provided by RefSeq]|
|Synonyms||156DAG antibody, A3a antibody, AGRNR antibody, DAG antibody, DAG1 antibody, dystroglycan antibody, dystroglycan 1 (dystrophin-associated glycoprotein 1) antibody|
|Cellular Localization||Alpha-dystroglycan: Secreted , extracellular space , Beta-dystroglycan: Cell membrane , Cytoplasm , cytoskeleton |
|Immunogen||Recombinant protein encompassing a sequence within the C-terminus region of human beta dystroglycan. The exact sequence is proprietary.|
|Species Reactivity||Human, Mouse|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Rat, Dog, Cat, Rabbit, Rhesus Monkey, Bovine|
|Predict Reactivity Note||Rat (87%), Dog (89%), Cat (94%), Rabbit (89%), Rhesus Monkey (97%), Bovine (91%)|