|Full Name||TYRO protein tyrosine kinase binding protein|
|Product Description||Rabbit Polyclonal antibody to DAP12 (TYRO protein tyrosine kinase binding protein)|
|Background||This gene encodes a transmembrane signaling polypeptide which contains an immunoreceptor tyrosine-based activation motif (ITAM) in its cytoplasmic domain. The encoded protein may associate with the killer-cell inhibitory receptor (KIR) family of membrane glycoproteins and may act as an activating signal transduction element. This protein may bind zeta-chain (TCR) associated protein kinase 70kDa (ZAP-70) and spleen tyrosine kinase (SYK) and play a role in signal transduction, bone modeling, brain myelination, and inflammation. Mutations within this gene have been associated with polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy (PLOSL), also known as Nasu-Hakola disease. Its putative receptor, triggering receptor expressed on myeloid cells 2 (TREM2), also causes PLOSL. Two alternative transcript variants encoding distinct isoforms have been identified for this gene. Other alternative splice variants have been described, but their full-length nature has not been deterimined. [provided by RefSeq]|
|Synonyms||DAP12 antibody, KARAP antibody, PLOSL antibody, TYROBP antibody, KAR-associated protein antibody, killer-activating receptor-associated protein antibody, DNAX-activation protein 12 antibody, killer activating receptor associated protein antibody, TYRO protein tyrosine kinase-binding protein antibody, TYRO protein tyrosine kinase binding protein antibody|
|Cellular Localization||Membrane; Single-pass type I membrane protein |
|Immunogen||Carrier-protein conjugated synthetic peptide encompassing a sequence within the C-terminus region of human DAP12. The exact sequence is proprietary.|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Dog, Rhesus Monkey, Bovine|
|Predict Reactivity Note||Dog (100%), Rhesus Monkey (100%), Bovine (100%)|