|Full Name||doublecortin-like kinase 2|
|Product Description||Rabbit polyclonal antibody to DCAMKL2 (doublecortin-like kinase 2)|
|Background||This gene encodes a member of the protein kinase superfamily and the doublecortin family. The protein encoded by this gene contains two N-terminal doublecortin domains, which bind microtubules and regulate microtubule polymerization, a C-terminal serine/threonine protein kinase domain, which shows substantial homology to Ca2+/calmodulin-dependent protein kinase, and a serine/proline-rich domain in between the doublecortin and the protein kinase domains, which mediates multiple protein-protein interactions. The microtubule-polymerizing activity of the encoded protein is independent of its protein kinase activity. Mouse studies show that the DCX gene, another family member, and this gene share function in the establishment of hippocampal organization and that their absence results in a severe epileptic phenotype and lethality, as described in human patients with lissencephaly. Multiple alternatively spliced transcript variants have been identified. [provided by RefSeq]|
|Synonyms||CL2 antibody, CLICK-II antibody, CLICK2 antibody, CLIK2 antibody, DCAMKL2 antibody, DCDC3 antibody, DCDC3B antibody, DCK2 antibody, DKFZp761I032 antibody, MGC45428 antibody, DCLK2 antibody, doublecortin and CaM kinase-like 2 antibody, doublecortin-like and CAM kinase-like 2 antibody, serine/threonine-protein kinase DCLK2 antibody, doublecortin domain-containing protein 3B antibody, CaMK-like CREB regulatory kinase 2 antibody, doublecortin-like kinase 2 antibody|
|Immunogen||Recombinant protein encompassing a sequence within the center region of human DCAMKL2. The exact sequence is proprietary.|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Predict Reactivity Note||Mouse (94%), Rat (95%)|