|Full Name||DCP1 decapping enzyme homolog A (S. cerevisiae)|
|Product Description||Goat polyclonal antibody to DCP1A|
|Background||Necessary for the degradation of mRNAs, both in normal mRNA turnover and in nonsense-mediated mRNA decay. Removes the 7-methyl guanine cap structure from mRNA molecules, yielding a 5'-phosphorylated mRNA fragment and 7m-GDP. Contributes to the transactivation of target genes after stimulation by TGFB1. |
|Synonyms||transcription factor SMIF, putative protein product of Nbla00360, Nbla00360, SMIF, Smad4interacting transcriptional coactivator, HSA275986, decapping enzyme hDcp1a, DCP1A, Smad4-interacting transcriptional co-activator, SMAD4IP1, decapping enzym, FLJ21691|
|Cellular Localization||Predominantly cytoplasmic, in processing bodies (PB). Nuclear, after TGFB1 treatment. Translocation to the nucleus depends on interaction with SMAD4. |
|Specificity||This antibody is specific for DCP1A.|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.