|Full Name||discoidin domain receptor tyrosine kinase 1|
|Product Description||Rabbit Polyclonal antibody to DDR1 (discoidin domain receptor tyrosine kinase 1)|
|Background||Receptor tyrosine kinases (RTKs) play a key role in the communication of cells with their microenvironment. These molecules are involved in the regulation of cell growth, differentiation and metabolism. The protein encoded by this gene is a RTK that is widely expressed in normal and transformed epithelial cells and is activated by various types of collagen. This protein belongs to a subfamily of tyrosine kinase receptors with a homology region to the Dictyostelium discoideum protein discoidin I in their extracellular domain. Its autophosphorylation is achieved by all collagens so far tested (type I to type VI). In situ studies and Northern-blot analysis showed that expression of this encoded protein is restricted to epithelial cells, particularly in the kidney, lung, gastrointestinal tract, and brain. In addition, this protein is significantly over-expressed in several human tumors from breast, ovarian, esophageal, and pediatric brain. This gene is located on chromosome 6p21.3 in proximity to several HLA class I genes. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq]|
|Synonyms||CAK antibody, CD167 antibody, DDR antibody, EDDR1 antibody, HGK2 antibody, MCK10 antibody, NEP antibody, NTRK4 antibody, PTK3 antibody, PTK3A antibody, RTK6 antibody, TRKE antibody, DDR1 antibody, mammary carcinoma kinase 10 antibody, "neurotrophic tyrosine kinase, receptor, type 4 antibody", epithelial discoidin domain-containing receptor 1 antibody, neuroepithelial tyrosine kinase antibody, PTK3A protein tyrosine kinase 3A antibody, tyrosine-protein kinase CAK antibody, CD167 antigen-like family member A antibody, protein-tyrosine kinase RTK-6 antibody, cell adhesion kinase antibody, tyrosine kinase DDR antibody, discoidin domain receptor tyrosine kinase 1 antibody|
|Cellular Localization||Isoform 1: Membrane , Isoform 2: Membrane , Isoform 3: Secreted , Isoform 4: Secreted |
|Immunogen||Recombinant protein encompassing a sequence within the C-terminus region of human DDR1. The exact sequence is proprietary.|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Mouse, Rat, Pig, Rhesus Monkey, Chimpanzee, Bovine|
|Predict Reactivity Note||Mouse (88%), Rat (88%), Pig (97%), Rhesus Monkey (98%), Chimpanzee (100%), Bovine (96%)|