|Full Name||DiGeorge syndrome critical region gene 8|
|Product Description||Goat polyclonal antibody to DGCR8 / Pasha|
|Background||This gene encodes a subunit of the microprocessor complex which mediates the biogenesis of microRNAs from the primary microRNA transcript. The encoded protein is a double-stranded RNA binding protein that functions as the non-catalytic subunit of the microprocessor complex. This protein is required for binding the double-stranded RNA substrate and facilitates cleavage of the RNA by the ribonuclease III protein, Drosha. Alternate splicing results in multiple transcript variants. [provided by RefSeq]|
|Synonyms||Gy1, pasha, DiGeorge syndrome critical region gene8, DGCRK6, DiGeorge syndrome critical region gene 8, DGCR8 / Pasha, DGCR8, C22orf12|
|Cellular Localization||Colocalizes with nucleolin and RNASEN/DROSHA in the nucleolus. Mostly detected in the nucleolus as electron-dense granular patches around the fibrillar center (FC) and granular component (GC). Also detected in the nucleoplasm as small foci adjacent to spl|
|Specificity||This antibody is specific for DGCR8 / Pasha.|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Human, Mouse, Rat, Bovine|