|Applications||ELISA, ICC/IF, IHC-F, IHC-P, IP, WB|
|Application Note||WB(1:100-500), ELISA(1:500-1000), IP(1:20-100), IHC-P(1:100-500), IHC-F(1:100-500), IF(1:100-500)|
(Please refer to the vial label for the specific concentration)|
|Purification||Purified by Protein A and peptide affinity chromatography.|
|Full Name||7-dehydrocholesterol reductase|
|Product Description||Rabbit Polyclonal antibody to DHCR7|
|Background||This gene encodes an enzyme that removes the C(7-8) double bond in the B ring of sterols and catalyzes the conversion of 7-dehydrocholesterol to cholesterol. This gene is ubiquitously expressed and its transmembrane protein localizes to the endoplasmic reticulum membrane and nuclear outer membrane. Mutations in this gene cause Smith-Lemli-Opitz syndrome (SLOS); a syndrome that is metabolically characterized by reduced serum cholesterol levels and elevated serum 7-dehydrocholesterol levels and phenotypically characterized by mental retardation, facial dysmorphism, syndactyly of second and third toes, and holoprosencephaly in severe cases to minimal physical abnormalities and near-normal intelligence in mild cases. Alternative splicing results in multiple transcript variants that encode the same protein.[provided by RefSeq, Aug 2009]|
|Synonyms||7-dehydrocholesterol reductase Antibody, SLOS Antibody|
|Immunogen||KLH conjugated synthetic peptide derived from human DHCR7|
|Species Reactivity||Human, Mouse, Rat|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Bovine, Horse, Chicken, Dog|