|Full Name||DEXH (Asp-Glu-X-His) box polypeptide 58|
|Product Description||Rabbit Polyclonal antibody to DHX58 (DEXH (Asp-Glu-X-His) box polypeptide 58)|
|Background||Participates in innate immune defense against viruses. Upon interaction with intracellular dsRNA produced during viral replication, triggers a transduction cascade which results in the induction and expression of antiviral cytokines such as IFN-beta and RANTES (CCL5). The RNA helicase domain may recognize and structurally modify viral RNA to facilitate detection by DDX58/RIG-I or by IFIH1/MDA5 whose affinity for dsRNA is lower. |
|Synonyms||D11LGP2 antibody, D11lgp2e antibody, LGP2 antibody, DHX58 antibody, RLR antibody, probable ATP-dependent helicase LGP2 antibody, probable ATP-dependent RNA helicase DHX58 antibody, protein D11Lgp2 homolog antibody, RNA helicase LGP2 antibody, RIG-I-like receptor LGP2 antibody, ortholog of mouse D11lgp2 antibody, DEXH (Asp-Glu-X-His) box polypeptide 58 antibody|
|Immunogen||Recombinant protein encompassing a sequence within the C-terminus region of human DHX58. The exact sequence is proprietary.|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Human, Mouse, Rat|
|Predict Reactivity Note||Human (100%), Mouse (81%), Rat (80%)|