|Full Name||dyskeratosis congenita 1, dyskerin|
|Product Description||Goat polyclonal antibody to DKC1|
|Background||Required for ribosome biogenesis and telomere maintenance. Probable catalytic subunit of H/ACA small nucleolar ribonucleoprotein (H/ACA snoRNP) complex, which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Each rRNA can contain up to 100 pseudouridine ('psi') residues, which may serve to stabilize the conformation of rRNAs. Also required for correct processing or intranuclear trafficking of TERC, the RNA component of the telomerase reverse transcriptase (TERT) holoenzyme. |
|Synonyms||DKC1, NOLA4, dyskeratosis congenita1, dyskerin, XAP101, DKC, NAP57, dyskeratosis congenita 1, dyskerin, CBF5, FLJ97620|
|Cellular Localization||Also localized to Cajal bodies. |
|Specificity||This antibody is specific for DKC1.|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
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