| Full Name | dickkopf homolog 1 (Xenopus laevis) |
| Product Description | Rabbit polyclonal antibody to DKK1 |
| Background | Xenopus Dickkopf (Dkk)-1 was initially discovered as a Wnt antagonist that plays an important role in head formation. By far, four members of Dkk have been identified in mammals. Each Dkk molecule contains two conserved cysteine-rich domains. Recent studies showed that the second Cys-rich domains of Dkk1 and Dkk2 inhibited Wnt-3a-activated signaling, whereas the first Cys-rich domains had no effects. In addition, the second Cys-rich domain of Dkk-2, but not that of Dkk-1, was able to activate the canonical pathway in the presence of LRP6, and this LRP-dependent signaling does not require Dvl. |
| Synonyms | DKK-1, DKK1, dickkopf1 like, dickkopf1, dickkopf homolog 1, dickkopf-1, dickkopf homolog1, SK, dickkopf-1 like, DKK 1, dickkopf 1, dickkopf 1 like |
| Specificity | This antibody is specific for DKK1. |
| Host | Rabbit |
| Clonality | Polyclonal |
| Target | DKK1 |
| Isotype | IgG |
| Species Reactivity | Human, Mouse, Rat |