|Full Name||mitogen-activated protein kinase kinase kinase 12|
|Product Description||Rabbit polyclonal antibody to DLK/MAP3K12 (mitogen-activated protein kinase kinase kinase 12)|
|Background||The protein encoded by this gene is a member of serine/threonine protein kinase family. This kinase contains a leucine-zipper domain, and is predominately expressed in neuronal cells. The phosphorylation state of this kinase in synaptic terminals was shown to be regulated by membrane depolarization via calcineurin. This kinase forms heterodimers with leucine zipper containing transcription factors, such as cAMP responsive element binding protein (CREB) and MYC, and thus may play a regulatory role in PKA or retinoic acid induced neuronal differentiation. [provided by RefSeq]|
|Synonyms||DLK antibody, MEKK12 antibody, MUK antibody, ZPK antibody, ZPKP1 antibody, MAP3K12 antibody, protein kinase MUK antibody, MAPK-upstream kinase antibody, dual leucine zipper bearing kinase antibody, leucine zipper protein kinase antibody, mixed lineage kinase antibody, mitogen-activated protein kinase kinase kinase 12 antibody, dual leucine zipper kinase DLK antibody|
|Cellular Localization||Cytoplasm (By similarity) , Membrane; Peripheral membrane protein |
|Immunogen||Recombinant protein encompassing a sequence within the N-terminus region of human ZPK. The exact sequence is proprietary.|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Human, Mouse, Rat, Zebrafish, Xenopus laevis, Rhesus Monkey, Bovine|
|Predict Reactivity Note||Human (100%), Mouse (100%), Rat (100%), Zebrafish (90%), Xenopus laevis (93%), Rhesus Monkey (100%), Bovine (100%)|