|Full Name||dystrophia myotonica-protein kinase|
|Product Description||Rabbit Polyclonal antibody to DMPK (dystrophia myotonica-protein kinase)|
|Background||The protein encoded by this gene is a serine-threonine kinase that is closely related to other kinases that interact with members of the Rho family of small GTPases. Substrates for this enzyme include myogenin, the beta-subunit of the L-type calcium channels, and phospholemman. The 3' untranslated region of this gene contains 5-37 copies of a CTG trinucleotide repeat. Expansion of this unstable motif to 50-5,000 copies causes myotonic dystrophy type I, which increases in severity with increasing repeat element copy number. Repeat expansion is associated with condensation of local chromatin structure that disrupts the expression of genes in this region. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined. [provided by RefSeq]|
|Synonyms||MDPK Antibody, DMK Antibody, DM1PK Antibody, MT-PK Antibody, DM1 Antibody, DM Antibody, dystrophia myotonica-protein kinase Antibody|
|Immunogen||Recombinant protein encompassing a sequence within the center region of human DMPK. The exact sequence is proprietary.|
|Species Reactivity||Human, Mouse|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Predict Reactivity Note||Rhesus Monkey (98%)|