|Full Name||cyclin D binding myb-like transcription factor 1|
|Product Description||Rabbit Polyclonal antibody to DMTF1 (cyclin D binding myb-like transcription factor 1)|
|Background||This gene encodes a transcription factor that contains a cyclin D-binding domain, three central Myb-like repeats, and two flanking acidic transactivation domains at the N- and C-termini. The encoded protein is induced by the oncogenic Ras signaling pathway and functions as a tumor suppressor by activating the transcription of ARF and thus the ARF-p53 pathway to arrest cell growth or induce apoptosis. It also activates the transcription of aminopeptidase N and may play a role in hematopoietic cell differentiation. The transcriptional activity of this protein is regulated by binding of D-cyclins. This gene is hemizygously deleted in approximately 40% of human non-small-cell lung cancer and is a potential prognostic and gene-therapy target for non-small-cell lung cancer. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq]|
|Synonyms||DMP1 antibody, DMTF antibody, FLJ25188 antibody, FLJ41265 antibody, FLJ76054 antibody, hDMP1 antibody, DMTF1 antibody, cyclin D-binding Myb-like protein antibody, hDMTF1 antibody, cyclin-D-interacting Myb-like protein 1 antibody, cyclin-D-binding Myb-like transcription factor 1 antibody, cyclin D binding myb-like transcription factor 1 antibody|
|Cellular Localization||Nucleus |
|Immunogen||Recombinant protein encompassing a sequence within the center region of human DMTF1. The exact sequence is proprietary.|
|Species Reactivity||Human, Mouse|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Chicken, Rhesus Monkey|
|Predict Reactivity Note||Chicken (89%), Rhesus Monkey (99%)|